Library
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Neuroendocrine tumors are a group of tumors that develop from the cells of the neuroendocrine system, and include insulinomas, gastrinomas, glucagonomas, carcinoids, medullary thyroid carcinomas, small-cell lung carcinomas, pheochromocytomas, chemodectomas, and Merkel cell carcinomas. This article discusses signs, diagnosis, treatment, and prognosis.
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A chemodectoma is a type of tumor made up of chemoreceptor cells. Chemoreceptor cells detect chemical changes in the body and respond by regulating chemical or physical processes. These tumors are most often seen along one of the carotid arteries and the aorta. Brachycephalic breeds are more predisposed to these types of tumors, though they may occur in any dog breed. These tumors are usually locally aggressive, however, there are rare cases of metastasis to other organs, including the lungs, lymph nodes, and bone.
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Odontogenic fibromas, sometimes previously referred to as an epulis, are benign tumors of the mouth often at the front of the upper jaw. These may be locally invasive and may cause some oral pain. Surgery is the recommended course of action to treat this condition.
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Oral squamous cell carcinomas (SCC) are the most common oral tumor in cats, and second most common in dogs. These tumors are locally aggressive, with a possibility to metastasize. Regardless of the location of SCC, surgery is the typically the standard treatment. Radiation therapy may be recommended following surgery or as a primary treatment for palliative care. Staging is recommended for all cases. If metastasis is present chemotherapy is often pursued.
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This handout discusses some of the more common forms of oral tumors in pets. Highlighted are Papillomas (“Warts”) and Fibropapillomas, both of wish are caused by viral infection. Clinical signs, diagnostic methods, and treatment options are highlighted.
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Ovarian tumors are quite rare in North American pets, mainly due to routine spaying practices. This handout discusses ovarian tumors in dogs and cats. The various forms of ovarian tumors, clinical signs, diagnosis, treatment, and prognosis of this cancer are outlined.
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Primary pancreatic tumors are rare in dogs and cats. Exocrine tumors include adenomas and adenocarcinomas, and endocrine tumors include insulinomas, gastrinomas, and glucagonomas. This article discusses signs, diagnosis, treatment, and prognosis.
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Parathyroid tumors are uncommon in dogs and cats. Benign adenomas occur more often than malignant tumors. Keeshonds appear to have a genetic predisposition to developing parathyroid tumors, but no breed or genetic relationship has been established in cats. Pets may exhibit signs of lethargy, little or no appetite, vomiting, and muscle twitching. Diagnosis is confirmed with PTH testing and ultrasound of the neck region after hypercalcemia is observed on bloodwork. Surgery to remove the affected gland(s) is the typical treatment, but ultrasound-guided ablation may be pursued. Careful monitoring of calcium levels post-surgery is important, as some pets may develop transient hypocalcemia and require calcium supplementation. Prognosis is excellent, and the metastatic rate for these tumors is extremely low.
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Clinical signs of pituitary tumors depend on whether the tumor is functional or non-functional. Functional tumors can cause Cushing's disease in dogs and can cause acromegaly and insulin-resistant diabetes in cats. Non-functional pituitary tumors can enlarge to cause neurological signs. Diagnosis is based on the history, bloodwork, urinalysis, and sometimes a CT scan or MRI. Medical therapy is often the treatment of choice for functional tumors. Radiation therapy is another option and is usually the primary treatment for non-functional tumors.
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Plasma cell tumors develop as a result of dysregulated production of plasma cells and are relatively uncommon in dogs and cats. Some plasma cell tumors are benign and the most common locations for these tumors are the head, feet, lips, mouth, and ears. The treatment of choice for benign plasma cell tumors is surgical removal, with little to no recurrence if completely excised. Conversely, multiple myeloma is a very malignant cancer that is usually treated with chemotherapy.