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  • Plasma cell tumors develop as a result of dysregulated production of plasma cells and are relatively uncommon in dogs and cats. Some plasma cell tumors are benign and the most common locations for these tumors are the head, feet, lips, mouth, and ears. The treatment of choice for benign plasma cell tumors is surgical removal, with little to no recurrence if completely excised. Conversely, multiple myeloma is a very malignant cancer that is usually treated with chemotherapy.

  • Platelet-rich plasma or PRP is a form of regenerative medicine where the platelet and protein components of blood are retrieved from a patient and then injected back into the patient at the site of inflammation. PRP contains growth factors that appear to promote tissue regeneration and reduce inflammation. The procedure is not yet widely available and should only be performed by a veterinarian with specialized equipment and special training in this area.

  • Polycythemia vera is a rare disease of dogs and cats in which too many red blood cells are produced by the bone marrow. The blood becomes thick and has difficulty moving through the small blood vessels. Your pet may feel tired, sluggish, and weak. Polycythemia is a potentially fatal disease, but if discovered early enough, treatment may be possible. If left untreated, polycythemia vera can affect the heart.

  • Polyethylene glycol is an off-label laxative used to treat constipation and empty the colon in preparation for procedures such as colonoscopy. The most common side effects are diarrhea, flatulence, and abdominal cramping. Do not use it in pets that are allergic to it or in pets with an intestinal blockage/obstruction.

  • Polymyxin B/miconazole/prednisolone otic (brand name Surolan), is a combination antibacterial (polymyxin B), antifungal (miconazole), and anti-inflammatory steroid (prednisolone) ear drop medication. It is used to treat ear infections in cats and dogs. It is used “off label” or “extra-label” in species other than cats and dogs and to treat conditions other than ear infections. Polymyxin B/miconazole/prednisolone otic comes in an otic suspension form.

  • Polysulfated glycosaminoglycan is an injectable disease-modifying osteoarthritis drug (DMOAD) used to treat non-infectious and traumatic arthritis in dogs. It is also used off-label in cats and small mammals. If administering this medication at home, follow your veterinarian’s instructions and dispose of the needle and syringe appropriately. Side effects are rare when given according to label recommendations and at prescribed intervals. Do not use this medication in pets with a known hypersensitivity to it, in pets with known or suspected bleeding disorders or immune-mediated arthritis, or in pets with severe kidney or liver disorders.

  • Ponazuril is given by mouth and is used on and off label to treat protozoal parasites in a variety of animal species. Side effects are uncommon but may include soft stools. Do not use in pets that are allergic to it. Ponazuril should be used cautiously in pregnant or lactating pets, and dogs with/susceptible to dry eye (keratoconjunctivitis sicca/KCS).

  • Potassium salts are given by mouth or an injection and are used on and off label to treat low blood potassium levels. Common side effects include nausea or discomfort. Do not use in pets that have high potassium levels, urination problems, tissue damage, uncontrolled Addison’s disease, gastrointestinal movement problems, or dehydration. If a negative reaction occurs, please call your veterinary office.

  • Povidone iodine topical (brand names Vetadine®, Poviderm®, Povidine®, others) is a topical antiseptic used on the skin prior to surgery and in first aid treatments for cats and dogs. It has been used in aquatic species and reptiles to treat fungal infections and wounds. Povidone iodine topical comes in liquid solution, gel, ointment, scrub, shampoo, and spray forms.

  • Pradofloxacin (brand name Veraflox®) is an antimicrobial medication used to treat bacterial infections. It is used to treat skin, urinary tract, and respiratory tract infections in cats. Pradofloxacin is approved for use in dogs in certain countries. It is used "off label" or "extra label" to treat other types of infections in cats and some types of infections in dogs.