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  • Pyridostigmine bromide is given by mouth or injection and is used off label to treat symptoms related to myasthenia gravis. Give as directed. Dose-related side effects include drooling, diarrhea, increased urination, abdominal pain, muscle cramps, and increased tear production. Do not use in pets that are allergic to it or other bromides, or in pets that have urinary or gastrointestinal tract obstructions or blockages. If a negative reaction occurs, please call your veterinary office.

  • Pyrimethamine is an antiprotozoal tablet given by mouth and used off-label to treat certain parasitic infections. Common side effects include vomiting, low appetite, tiredness, and low blood cell counts. Cats are more likely to have more severe side effects. Pregnant women should handle this medication carefully.

  • Radiation is a type of energy produced naturally by the sun, earth, and rocks and artificially by machines. Although several types of tumors can be treated with radiation therapy alone (e.g., nasal tumors, brain tumors, and certain types of lymphoma), radiation therapy is most commonly used to destroy or limit the growth of cancer cells left behind (i.e., microscopic disease) after a tumor has been surgically removed. Side effects depend on the type and location of the tumor and its surrounding tissues.

  • Ranitidine is given by mouth or injection and is used off-label to treat ulcers and erosions in the stomach and upper small intestine, reflux, or gastrointestinal motility issues. Give as directed. Side effects are uncommon but may include stomach upset. Do not use in pets with a history of allergies to this class of drugs. If a negative reaction occurs, call your veterinarian.

  • Counterconditioning occurs when the pet's reaction (emotional response) to a stimulus is changed from one that is anxious or fearful to one that is positive and enjoyable. To accomplish this, favored rewards should be paired with each exposure to the stimulus.

  • This handout provides a brief overview of the most common evidence-based modalities used in veterinary medicine. Pet owners need to discuss the risk of recommended modalities for their specific pet with a trained and certified rehabilitation therapist before starting a rehabilitation program.

  • Retinal detachment can cause sudden blindness or vision changes. It is generally secondary to an underlying condition like high blood pressure. Diagnostics and treatment are discussed. Prognosis is guarded to good depending on the underlying cause.

  • Rifampin is commonly used off label to treat infections in horses, and occasionally in dogs and cats. It is usually given by mouth in the form of a capsule or compounded liquid. The most common side effects are vomiting, diarrhea, or reduced appetite. Liver dysfunction is possible. A change in the color of urine, tears, and saliva to a red/orange color is expected but may stain fabrics. Use with caution in pets that have pre-existing liver disease, are pregnant, are elderly, or are lactating. If a negative reaction occurs, call your veterinary office.

  • Anesthesia-free dentistry is commonly offered at pet stores and grooming facilities. It is more limited than veterinary dentistry, and often a higher-stress option with more potential for injury from sharp instruments. Dental cleanings should only be performed while your pet is under anesthesia. Your veterinarian will customize your pet's anesthetic plan for your pet's overall health.

  • Robenacoxib (brand name: Onsior) is given by mouth in the form of a tablet to treat pain and inflammation associated with surgery or other musculoskeletal conditions in dogs and cats. Do not use this medication in pets that are allergic to it, or in pets concurrently using corticosteroids or other NSAIDs. If a negative reaction occurs, call your veterinary office.