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Weakness can be caused by many different problems and can involve a variety of body systems. Finding the cause of your pet’s weakness starts with a complete history and physical examination. The most commonly recommended screening tests for weakness include complete blood count, serum biochemistry profile, urinalysis, and in a dog, total thyroxine. Additional tests may be recommended based on the results of these screening tests.
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Weight loss in dogs can be caused by many conditions including inadequate intake to meet energy requirements, poor quality nutrition, and many different medical conditions. Testing for weight loss starts with a thorough history and physical exam. If the cause of weight loss is not clear, then screening tests including a CBC, biochemistry, urinalysis, and fecal tests are performed to further investigate. Based on the results of these tests, more specific diagnostic tests such as imaging, bile acids, or ACTH stimulation may be needed to determine the reason for the weight loss.
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The most common disorder of the thyroid gland in dogs is hypothyroidism. Diagnosis of hypothyroidism includes a complete blood count, biochemistry profile, urinalysis, and thyroid-related hormones. Mild anemia, elevated cholesterol and mildly elevated liver and kidney enzymes are supportive of a diagnosis of hypothyroidism. A combination of clinical signs and measurements of total T4, free T4 by equilibrium dialysis, and thyroid stimulating hormone (TSH) is generally used to confirm a diagnosis.
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Trypsin-like immunoreactivity (TLI) is a blood test that measures the amount of a pancreatic proenzyme called trypsinogen. This measurement correlates with the amount of pancreatic enzymes released into the intestine to aid in digestion. A low measurement indicates exocrine pancreatic insufficiency. Concurrent pancreatitis or tests done shortly after a meal may temporarily increase this measurement to a normal value (false negative).
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Damage to the tympanic membrane and middle ear infections can be very painful for dogs and cause a variety of clinical signs affecting the skin and nervous system. Diagnosis often requires a thorough ear examination with testing while your dog is under sedation or anesthesia. The treatment methods and prognosis depend on the nature of your dog's condition.
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Ultrasound uses the reflection of sound waves to generate an image of internal structures allowing for identification of masses, pregnancy diagnosis, abnormal heart function and muscle size, abnormalities of the orbit, and abnormal appearance of abdominal organs. Ultrasound results can be analyzed in real time; however, assessment by a radiologist may take several days. Ultrasound is an invaluable tool to detect problems in a non-invasive fashion.
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Urinalysis is an important part of any comprehensive workup or health screen. It provides information on the urinary system including the kidneys and bladder and also can support diagnosis of metabolic disease, such as diabetes mellitus.
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Cortisol is a stress hormone that is excreted from the body in the urine. Creatinine is a product of muscle metabolism and is normally lost in the urine at a relatively steady rate. The ratio of creatinine to cortisol in the urine can be used to account for the effect of urine concentration on cortisol measurements. Urine cortisol/creatinine ratio is usually evaluated in animals suspected of having Cushing's disease. This test involves the collection of a single urine sample, taken first thing in the morning.
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The presence of protein in urine is called proteinuria, and it may indicate that the kidneys are not working properly. In some situations, proteinuria may even be a sign of kidney failure; however, bleeding or inflammation in the urinary system is a far more common cause. Your veterinarian may recommend further testing if the urinalysis reveals inflammation or bleeding.
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The urine protein/creatinine (UPC) ratio is a test that measures how much protein is being lost through the kidneys. The UPC measures whether protein excretion is greater than expected when compared to the excretion of creatinine. Before the UPC ratio can be interpreted, two other measures of kidney function should be taken: blood urea nitrogen (BUN) and serum creatinine.